![]() Most (80%) of the protein in the CSF is derived from the blood, with only 20% from local synthesis within the CNS itself. The CSF metabolome is a live online database of the chemical content of the cerebrospinal fluid 6. CSF is a component of, and is continuous with, the interstitial fluid of the central nervous system (CNS). Normal volume ranges differ depending on the source but are generally in the 150-250 mL range with approximately 700 mL produced daily, hence the entire CSF volume is replaced 3-4 times per day. Cerebrospinal fluid (CSF) is present within the ventricular system of the brain, the central canal of the spinal cord, and the subarachnoid space (SAS) between the pia mater and the arachnoid mater. Two-way transport of water and solutes across the blood-brain barrier and also between the CSF and interstitium at cellular membranes To-and-fro: due to pulsatile flow in the cerebral arteries The mechanisms producing the circulation of CSF is complex, and is thought to be due to a combination of 5:īulk flow: pressure gradient between choroid plexus and arachnoid granulations Up to 15% of CSF drains into the lymphatics within the perineural spaces of the cranial and spinal nerves 5. The majority of CSF is absorbed into the venous system by the arachnoid villi, which protrude into the dural venous system around the brain, particularly the superior sagittal sinus and transverse sinuses. Physiology ProductionĬerebrospinal fluid is produced by the epithelium of the choroid plexus within the ventricular system and flows in the direction from the lateral ventricles to the third ventricle, then fourth ventricle and then around the brain and spinal cord. Cerebrospinal fluid ( CSF) is the clear liquid that surrounds and bathes the brain and spinal cord.
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